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Objectives: to assess the absolute fracture risk in outpatients with osteoporosis (OP) at distant radius. Methods: individual absolute fracture risk was assessed using FRAX tool without hip neck bone mineral density (BMD) input in 3082 subsequent subjects (2911 females and 171 males) aged from 40 to 95 (median age 60), calculated by Finnish population data. Distant radius BMD was estimated in all patients by DTX200. Results: 774 (25.1 %) patients had had history of low traumatic fractures. BMD≤- .5 SD was detected in 1659 cases, fracture history in 558 (33.6%) of them (OR = 2.21; 95 % CI 1.93-2.55). Median 10-year probability of a major osteoporotic fracture was 4.90 % (25- 75 %; 1.10 - 55.0) and 10-year probability of a hip fracture was 0.8 % (0 - 46), absolute risk 10 % and higher was detected in 434 (64,3 %) patients. Calculated 10-year probability of a major osteoporotic fracture > 10 % was associated with previous low traumatic fractures: OR = 4,55; 95 % CI 4,06- 5,10, test sensitivity being 56.1 % with specificity 89.6 % . The same association was found for 10-year probability of hip fracture >3 %: OR = 3.57 (3.19 - 4.00), test sensitivity being 51,6 % with specificity 86,7 %. Conclusion: FRAX tool for individual absolute fracture risk assessment should be introduced into general practice for clinical decision making in prophylaxis of OP associated fractures.

About the authors

A A Popov

Email: art_popov@mail.ru
doktor meditsinskikh nauk, dotsent kafedry vnutrennikh bolezney № 2

M V Strunina

M V Telyushchenko


  1. Аудит состояния проблемы остеопороза в странах Восточной Европы и центральной Азии 2010. - Международный Фонд Остеопороза, 2011. - 64 с.
  2. Верткин А.Л., Наумов А.В., Шамуилова М.М., Коцелапова Э.Ю., Мендель О.И. Международный опыт и российский менталитет в профилактике и лечении остеопороза // Русский медицинский журнал. - 2010. Том 18, N 2. - С. 55 - 59
  3. Лесняк О.М., Евстигнеева Л.П., Коваль А.М. и др. Приверженность российских пациентов лечению остеопороза (национальный проект «Сила в постоянстве») // Фарматека, 2008 - №3 (157). -С. 73 - 79.
  4. Лесняк Ю. Ф. Фармакоэкономические аспекты проблемы остеопороза: анализ желания пациентов платить за лечение / Ю. Ф. Лесняк, Л. П. Евстигнеева, О. М. Лесняк // Ревматология. - 2005. - № 1. - С. 12 - 17.
  5. Остеопороз / под ред. О.М. Лесняк, Л.И. Беневоленской. - 2-е изд., перераб. и доп. - М.: ГЭОТАР - Медия, 2010. - 272 с. - (Серия «Клинические рекомендации»).
  6. Хельсинкская Декларация. Рекомендации для врачей, проводящих медико-биологические исследования с участием людей. Приняты 18-й Всемирной медицинской ассамблеей (Хельсинки, 1964 г.), Пересмотрены 41-й Всемирной медицинской ассамблеей (Гонконг, 1989 г.): пер. с англ. www.mediasphera.ru/recom/hels.htm.
  7. Одномоментное исследование частоты выявления остеопении и остеопороза дистального отдела предплечья у жительниц Перми 50 лет и старше / А.А. Попов, Н.В. Изможерова, М.В. Струнина, М.В. Телющенко // Тер. Архив. 2009. - № 11. - С. 52 - 56.
  8. Blank R.D.; FRAX (®) Position Development Conference Members. Official Positions for FRAX® clinical regarding prior fractures from Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®. J. Clin. Densitom. 2011;14 (3): 205 - 11.
  9. Compston J.E., Watts N.B., Chapurlat R., Cooper C., Boonen S., et al. for the Glow Investigators. Obesity Is Not Protective against Fracture in Postmenopausal Women: GLOW. Am J Med. 2011; 124: 1043 - 1050.
  10. Gonzalez-Madas J., Marin F., Vila J., Diez - Pérez A. Probability of fractures predicted by FRAX® and observed incidence in the Spanish ECOSAP Study cohort. Bone. 2012; 50(1): 373 - 7.
  11. Kanis J.A., Johnell O., Oden A., Johansson H., Closkey E.Mc. FRAX™ and the assessment of fracture probability in men and women from the UK. // Osteoporos. Int.- 2008.- 19: 385-397.
  12. Kanis J.A., on behalf of the World Health Organization Scientific Group Assessment of osteoporosis at the primary health-care level. Technical Report. WHO Collaborating Centre, University of Sheffield, uK. 2008.
  13. Masud T., Binkley N., Boonen S., Hannan M.T.; FRAX(®) Position Development Conference Members. Official Positions for FRAX® clinical regarding falls and frailty: can falls and frailty be used in FRAX®? From Joint Official Positions Development Conference of the International Society for Clinical Densitometry and International Osteoporosis Foundation on FRAX®.J Clin Densitom. 2011;14 (3): 194 - 204.
  14. National Osteoporosis Guideline Group. Guidelines for the diagnosis and management of osteoporosis in postmenopausal women and men from the age of 50 years in the UK. J. Compston, A. Cooper, C. Cooper, R. Francis, J.A. Kanis, D. Marsh, E.V. McCloskey, D.M. Reid, P. Selby and M. Wilkins, on behalf of the National Osteoporosis Guideline Group (NOGG). Updated July 2010. Univesity of Sheffield Press, UK. 2010.
  15. Osteoporosis in the European Union in 2008: Ten years of progress and ongoing challenges. Доступ: http://www.iofbonehealth.org/download/osteofound/filema-nager/publications/pdf/eu-report-2008.pdf
  16. Siris E., Delmas P.D. Assessment of 10-year absolute fracture risk: a new paradigm with worldwide application // Osteoporos Int, 2008; 19: 383-384.
  17. World Health Organization. Assessment of osteoporosis at the primary health care level. WHO, Geneva, 2008.
  18. http://www.pogoda.ru.net/climate/28224.htm.



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Copyright (c) 2012 Popov A.A., Strunina M.V., Telyushchenko M.V.

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