FRACTURE HEALING AND ANTIOSTEOPOROTIC TREATMENT

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Abstract


«Переломы широко распространены у пациентов с остеопорозом. По данным эпидемиологических исследований, частота возникновения переломов длинных костей в популяции экспоненциально увеличивается с возрастом, что является серьезной проблемой в связи с повышением заболеваемости и смертности среди лиц пожилого возраста. Несмотря на доступность препаратов для лечения ОП, достоверно снижающих риск переломов, практически у половины пациентов пожилого возраста на протяжении последующих лет жизни возникает как минимум один перелом. В этой связи, консолидация переломов у пациентов, уже получающих лечение, представляет собой клинически значимую проблему».

About the authors

George P. Lyritis

Laboratoriya po izucheniyu myshechno-skeletnoy sistemy, Gospital' KAT.

References

  1. McKibbin В. The biology of fracture healing in long bones. J Bone Jornt Surg. Br. 1978; 60B: 150-162.
  2. Frost H.M. The biology of fracture healing. An overview for clinicians. Part I. Ciin Orthop. 1989; 248: 150-162.
  3. Frost H.M. The Microdamage (MDx) Connection. In; Frost HM. The Utah Para of Skeletal Physiology Vol. 1. Athens, Greece: ISMNI; 2004; 4: 208-219.
  4. Gerstenfeld I.C., Cullinane D.M., Barnes G.L., Graves D.T., Einhom T.A. Fracture healing as а post-natal developmental process: molecular, spatial, and temporal aspects of its regulation. J Cell Biochem. 2003; 88: 873-884.
  5. AI-Aql Z.S., Alagi A.S., Graves D.T., Gerstenfeld I.C., Einhorn T.A. Molecular mechanisms controlling bone formation during fracture heading and distraction osteogenesis. J Dent Res. 2008; 87; 107-118.
  6. Lyritis G.P. The history of the walls of the Acropolis of Athens and the natural history of secondary fracture heading process. J Musculoskel Neuronal Interact. 2000; 1: 1-3.
  7. Barrios С., Brostrom L.A., Stark А., Walheim G. Healing complications after internal fixation of trochanteric hip fractures: the prognostic values of osteoporosis. J Orthop Trauma. 1993; 7: 438-442.
  8. Meyer R.A. Jr., Tsahakis P.J., Martin D.F., Banks D.M., Harrow M.E., Kiebzak G.M. Age and ovariectomy impair both the normalization of mechanical properties and the accretion of mineral by the fracture callus in rats. J Orthop Res. 2001; 19: 428-435.
  9. Backwaiter J.A., Einhorn Т.А., Вокпсег M.E., Cruess И. Healing of the muscuioskeletal tissues. In: Heckman JD., ed. Fractures in adu/ts, 4th ed, Philadelphia, NY; Lippincott-Raven; 1996; 261-304.
  10. Nieminen S., Nurmi M., Satokari К. Healing of femoral neck fractures; influence of fracture reduction and age. Ann Chir Gynaecol. 1981; 70: 26-31.
  11. Waters R.V., Gamradt S.C., Asnis P., et al. Systemic corticosteroids inhibit bone healing in а rabbit ulnar osteotomy model. Acta Orthop Scand. 2000; 71: 316-321.
  12. Augat P., Simon U., Liedert А., Claes L. Mechanics and mechano-biology of fracture heaing in normal and osteoporotic bone. Osteoporos Int. 2005; 16: S36-S43.
  13. Obrant K.J., Ivaska К.К., Gerdhem P., Alatalo S.L., Pettersson К., Vaananen H.K. Biochemical markers of bone turnover are influenced by recently sustained fracture. Bone. 2005: 36: 786-792.
  14. Kanis J.А. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002; 359: 1 929-1936.
  15. Cummings S.R., Melton L. Jr. Epidemiology and outcomes of osteoporotic fractures. Lancet. 2000; 359: 1761-1767.
  16. Lewiecki E.M. Emerging drugs for postmenopausal osteoporosis. Expert Opin Emerg Drags. 2009; 14: 129-144.
  17. Riggs B.L., Parfitt А.М. Drugs used to treat osteoporosis: the critical need for а uniform nomenclature based on their action on bone remodeling. J Bone Miner Res. 2005,20: 177-184.
  18. Goldhahn J., Scheele W.H., Mitlak В.Н. et al. Clinical evaluation of medicinal products for acceleration of fracture heading in patients with osteoporosis. Bone. 2008; 43: 343-347.
  19. Goldhahn J., Mitlak В., Aspenberg P., Kanis J.A., Rizzoli R., Register J.Y.; GREES (Group for Respect of Ethics and Excellence in Science) Working Group on Bone Fracture-Healing. Critical issues in translational and clinical research for the study of new technologies to enhance bone repair. J Bone Joint Surg Am. 2008; 90(suppl 1): 43-47.
  20. Aspenberg P Drugs and fracture repair. Acta Orthop. 2005; 76: 241-248.
  21. Bhandari M., Guyalt G.H., Swiontkowski M.F., Torneta P. III, Sprague S., Schemitsch E.H. А lack of consensus in the assessment of fracture healing among orthopaedic surgeons. J Orthop Trauma. 2002; 16: 562-566.
  22. Namkung-Matthai Н., Appleyard R., Jansen J., et al. Osteoporosis influences the early period of fracture heading in а rat osteoporotic model. Bone. 2001; 28: 80-86.
  23. Walsh W.R., Sherman P., Hewlett C.R., Sonnabend D.H., Ehriich M.G. Fracture healing in а rat osteopenia model. Clin Orthop. 1997; 218-227.
  24. Peter С., Cook W., Nunamaker D., Provost M., Seedor J., Rodan G. Effect of alendronate on fracture heading and bone remodeling in dogs, J Orthop Res. 1996; 14: 74-79.
  25. Goodship А., Walker P., McNally D., Chambers Т., Green J. Use of а bisphosphonate (pamidronate) to modulate fracture repair in ovine bane. Ann Oncol. 1994; 5 (suppi 7); 553-555.
  26. Li J., Mori S., Kaji Y., Mashiba T., Kawanishi J., Norimatsu Н. Long-term effect of incadronate disodium (YM-175) on fracture healing of femoral shaft in growing rats. J Bone Miner Res. 2001; 16: 429-436.
  27. Habermann В., Olender G., Eberhardt С., Augat P. Ibandronate affects callus formation and mechanical properties during fracture repair in ovariectomized Sprague-Dawley rats after 4 weeks of treatment. Bone, 2008; 42: S53.
  28. Amanat N., Hong Не L., Swain M.V., Little D.G. The effect of zoledronic acid on the intrinsic material properties of healing bone: An indentation study. Med Eng Phys. 2008; 30: 843-847.
  29. McDonald M.M., Dulai В., Godfrey С., Amanat N., Sztynda T., Little D.G. Bolus or weekly zoledronic acid administration does not delay endochondral fracture repair but weekly dosing enhances delays in hard tissue remodeling. Bone 2008: 43: 653-662.
  30. Greiner S.H., Wildelmann В., Васk D.A., et al. Local application of zoledronic acid incorporated in а poly (D.,L-lactide) - coated implant accelerates fracture healing in rats, Acta Orthop. 2008; 79: 717-725.
  31. Fleisch Н. Can bisphosphonates be given to patients with fractures? J Bone Miner Res. 2001; 16: 437-440.
  32. van der Poest, Patka Р., Vandronmael К., Нааrrmаn Н., Lips P. The effect of alendronate on bone mass after distal forearm fracture. J Bone Miner Res. 2000 15: 586-593.
  33. Odvina С., Zerwekh J., Rao D., Maalouf N., Gottschalk F., Park С. Severeiy suppressed bone turnover: А potential complication of alendronate therapy. J Clin Endocrinol Metab. 2005; 90: 1294-1301.
  34. Johnson Lynn S.E., Francis R., McCaskie А. Osteoporosis treatments and their effect an fracture healing. Curr Orthop. 2008; 22: 336-340.
  35. Chapurlat R.D., Delmas P.D. Bone microdamage: А clinical perspective, Osfeoporos Int. 2009; 20: 1299-1308.
  36. Shima Y., Engebretsen L., Iwasa J., Kitaoka К., Tomita К. Use of bisphosphonates for the treatment of stress fractures in athletes. Knee Surg Traumatol Arthrosc. 2009; 17: 547-550.
  37. Lenart В.А., Neviaser A.S., Lyman S., et al. Association of low-energy femoral fractures with prolonged bisphosphonate use: а case control study. Osfeoporos Int. 2009; 20: 1457-1458.
  38. Sayed-Noor A.S., Sjoden G.O. Subtrochanteric displaced insufficiency fracture after long-term alendronate therapy-а case report. Acta Orthop, 2008; 79: 565-567.
  39. Abrahamsen В., Eiken P., Eastell R. Subtrochanteric and diaphyseai femur fractures in patients treated with alendronate. А registered-based national соhort;. J Bone Miner Res, 2009: 24: 1095-1102.
  40. Sayed-Noor A.S., Sjoden G.O., Case reports: Two femoral insufficiency fractures after long-term alendronate therapy. Clin Orthop Relat Res. 2009, 467: 1921-1926.
  41. Somford M.P., Draijer F.W., Thomassen B.J., Chavassieux P.M., Воivin G., Papapoulos S.E. Bilateral fractures of the femur diaphysis in а patient with rheumatoid arthritis on long-term treatment with alendronate: clues to the mechanism of increased bone fragility. J Bone Miner Res, 2009; 24: 1736-1740.
  42. Nozaka К., Miyakoshi N., Kasukawa Y., Maekawa S., Noguchi Н., Shimada Y. Intermittent administration of human parathyroid hormone enhances bone formation and union at the site of cancellous bone osteotomy in normal and ovariectomized rats. Bone, 2008; 42: 90-97.
  43. Cipriano С.А., Issack P.S., Shindle L., Werner C.M., Helfet D.L., Lane І.М. Recent advanced toward the clinical application of PTH (1-34) in fracture healing. HSS J. 2009; 5: 149-153.
  44. Rizzoli R. А new treatment for post-menopausal osteoporosis: strontium ranelate. J Endocrinol lnvest. 2005; 28(suppt 8): 50-57.
  45. Cebosoy О., Tutar Е., Kose К.C., Baltaci Y., Bagci С. Effect of strontium ranelate on fracture healing in rat tibia. Joint Bone Spine. 2007; 74: 590-593.
  46. Wong K.L., Liu W.C., Pan H.B., et al. Mechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketo composites. Biomaterials. 2009; 30: 3810-3817.
  47. Habermann В., Olender G., Eberhardt С., Augat P., Kurth А.А. Strontium ranelate and teriparatide (PTH 1-34) enhance fracture healing in osteoporotic Sprague Dawley rats. J Bone Miner Res. 2008; 23(suppl 1): S206.
  48. Stuermer Е.К., Sehmisch S., Rack Т., et al. Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. А new fracturehealing model at the tibia in rat, Langenbecks Arch Surg. 2008 Dec 2. Epub ahead of print.
  49. Delgado-Martinez A.D., Martinez М.Е., Carrascal M.T., Rodriguez Avial М., Munuera I. Effect of 25-OН-vitamin D on fracture healing in elderly rats. J Orthop Res. 1998; 16: 650-653.
  50. Doetsch A.M., Faber J., Lynnerup N., Watzen I., Bliddal Н., Danneskiold-Samsoe В. Thе effect of calcium and vitamin D3 supplementation on the healing of the proximal humerus fracture: А randomized placebo-controlled study. Calcif Tissue Int. 2004; 75: 183-188.
  51. Lyritis G.P., Boscainos P.J. Calcitonin effects on cartilage and fracture healing. J Musculoskel Neuron Interact. 2001; 2: 137-142.
  52. Li Y., Tan Y., Zhang G., Yang В., Zhang J. Effects of calcitonin Gene-Related Peptide on the expression and activity of Nitric Oxide Synthase during mandibular bone healing in rabbits: An Experimental study. I Oral MaxIIIofac Surg. 2009; 67: 273-279.

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