Axial and periferal bone mineral density (BMD) was estimated by DXA twice within 1-47 months in 16 patients following orthotopic liver transplantation (OLT). Osteoporosis and osteopenia of lumbar spine and hip were identified in the first examination of all 9 recipients (group 1) with primary biliary cirrhosis (PBC) and in 5 out of 7 (71%) patients with viral hepatitic cirrhosis (group 2). Recipients which were firstly examined within 1-7 months following OLT (subgroups 1A, 2A) through 9±2.8 months showed in 1A axial BMD elevation (on 20.7+13.2% ; P=0.024) and in 2A axial so as hip BMD elevation (on 10.5+2.7%;P=0.001 and 8.1+5.9%;P< 0.05). Recipients which were examined later 18 months after OLT demonstrated no increase in BMD (subgroups 1B and 2B). Moreover two of them with PBC showed decrease in BMD, probably, as a result of transplant dysfunction and immunosuppression with glucocorticoids.

About the authors

I P Ermakova

Ya G Moysyuk

V P Buzulina

T K Koliashvili

E B Yaroshenko

M N Kornilov

I A Pronchenko

N P Shmerko


  1. Collier J. Bone disorders in chronic liver disease. // Hepatology. 2007. V.46. P. 1271-1278.
  2. Compston J.E. Osteoporosis after liver transplantation.// Liver Transpl. 2003; V. 9. P 321-330.
  3. Crosbie O.M., Freaney R., McKenna M.J. et al. Predicting bone loss following orthotopic liver transplantation.// Gut. 1999; V. 44. P. 430-434.
  4. Eastell R., Dickson E.R., Hodgson S.F. et al. Rates of vertebral bone loss before and after liver transplantation in women with primary biliary cirrhosis.// J. Hepatology. 1991; V.14. P. 296-300.
  5. Floreani A., Fries W., Luisetto G. et al. Bone metabolism in ortopic liver transplantation: prospective study.// Liver Transpl. 1998; V.4. P. 311-319.
  6. Gasser R.W. Cholestasis and metabolic bone disease - a clinical review.// Wien Med Wochenschr. 2008; V.158 (19-20). P. 553-557.
  7. Guichelaar M.M.J., Kendall R., Malinchoc M. et al. Bone mineral density before and after OLT: long-term follow-up and predictive factors.// Liver Transplantation. 2006; V. 12. P. 1390-1402.
  8. Mart G., Gomez R., Jodar E. et al. Long-term follow-up of bone mass after orthotopic liver transplantation: effect of steroid withdrawal from the immunosuppressive regimen.// Osteoporos Int. 2002; V. 13. P. 147-150.
  9. McDonald J.A., Dunstan C.R., Dilworth P. et al. Bone loss after liver transplantation.// Hepatology. 1991; V. 14(4Pt 1). P. 613-619.
  10. Monegal A., Navasa M., Guanabens N. et al. Bone disease after liver transplantation: a long-term prospective study of bone mass changes, hormonal disorders and histomorphometric characteristics.// Osteoporos Int. 2001; V12. P. 484-492.
  11. Monegal A., Navasa M., Guanabens N. et al. Bone mass and mineral metabolism in liver transplant patients treated with FK506 or cyclosporine A.// Calcif Tissue Int. 2001; V. 68. P. 83-86.
  12. Mounach A., Ouzzif Z., Wariaghli G. et al. Primary biliary cirrhosis and osteoporosis: a case-control study // J Bone Miner Metab. 2008; V. 26. P. 379-384.
  13. Newton J., Francis R., Prince M. et al. Osteoporosis in primary biliary cirrhosis revisited.// Gut. 2001; V. 49. P. 282-287.
  14. Segal E., Baruch Y., Kramsky R. et al. Predominant factors associated with bone loss in liver transplant patients - after prolonged posttransplantation period.// Clin. Transplant. 2003; V. 17(1). P. 13-19.
  15. Trautwein C., Possienke M., Schlitt H.J. et al. Bone density and metabolism in patients with viral hepatitis and cholestatic liver diseases before and after liver transplantation.// Am. J Gastroenterol. 2000; V. 95. P. 2343-2351.



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Copyright (c) 2009 Ermakova I.P., Moysyuk Y.G., Buzulina V.P., Koliashvili T.K., Yaroshenko E.B., Kornilov M.N., Pronchenko I.A., Shmerko N.P.

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