MOLEKULYaRNO-GENETIChESKIE MARKERY OSTEOPOROZA U ZhITELEY BLOKADNOGO LENINGRADA

Abstract


The aim of our study is researching influence of vitamin D and osteocalcin polymorphic gene markers in people, who lived in Blockaded Leningrad in 1941-1944 and detecting “critical age” of peak bone mass formation in these people. We included in our study 48 peoples, 13 males and 35 females. Osteodensitometry of lumbar spine (L1-L4) and proximal hip was used by dualenergy X-ray absorptiometer GE Lunar Prodigy Vision 6. Molecular diagnostic researching are: detecting ApaI, TagI vitamin D receptor (VDR) and HindIII osteocalcin gene polymorphism by polymerase chain reaction with restriction assay. Women with osteopenia of hip neck had significantly higher age in the onset of Blockade, than women without osteopenia. Genotype ТТ and allele Т of TagI, aa genotype of ApaI VDR, genotype hh and allele h of HindIII osteocalcin gene polymorphism will be able as markers of genetic predisposing to osteoporosis in people, who lived in Blockaded Leningrad.

About the authors

O N Semenova

glavnyy vrach

M M Kostik

S I Yagashkina

M A Bogdanova

A N Voytovich

O S Romashkina

L A Shcheplyagina

V I Larionova

References

  1. Рожинская Л.Я. Системный остеопороз. Практическое руководство для врачей. М.: Издатель Мокеев, 2000; 196.
  2. Беневоленская Л.И. Руководство по остеопорозу. М.: БИНОМ. Лаборатория знаний, 2003; 524.
  3. Aerssens J., Dequeker J., Peeters J., Breemans S., Broos P., Boonen S. Polymorphisms of the VDR., ER and COLIA1 genes and osteoporotic hip fracture in elderly postmenopausal women. Osteoporos Int. 2000; 11 (7): 583-91.
  4. Grundberg E., Brandstrom H., Ribom E.L., Ljunggren O., Mallmin H., Kindmark A. Genetic variation in the human vitamin D receptor is associated with muscle strength, fat mass and body weight in Swedish women. Eur. J Endocrinol. 2004; 150 (3): 323-8.
  5. Sheehan D., Bennett T., Cashman K. The genetics of osteoporosis: vitamin D receptor gene polymorphisms and circulating osteocalcin in healthy Irish adults. J Med. Sci. 2001; 170(1): 54-7.
  6. Deng H.W., Shen H., Xu F.H., Deng H.Y., Conway T., Zhang H.T., Recker R.R. Tests of linkage and/or association of genes for vitamin D receptor, osteocalcin, and parathyroid hormone with bone mineral density. J Bone. Miner. Res. 2002; 17(4): 678-86.
  7. Dohi Y., Iki M., Ohgushi H., et al. A novel polymorphism in the promoter region for the human osteocalcin gene: the possibility of a correlation with bone mineral density in postmenopausal Japanese women. J Bone miner. Res. 1998; 13: 1633-9.

Statistics

Views

Abstract - 838

PDF (Russian) - 639

Cited-By


PlumX

Dimensions


Copyright (c) 2011 Semenova O.N., Kostik M.M., Yagashkina S.I., Bogdanova M.A., Voytovich A.N., Romashkina O.S., Shcheplyagina L.A., Larionova V.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies