DRUG USERS-RISK FACTOR OF OSTEOPOROSIS

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Abstract


Osteoporosis is one of the main problems in the world health care. Typical for osteoporosis is the progressive decrease of the bone mass, destruction of the bone micro-architectonics wich leads to increase the bone fragility, and a high frequency of the bone fractures. Osteoporosis was considered as pathology associated with gender. Up to recent times there was accepted that frequency of osteoporosis (OP) was higher in females. Though, during last few years the numerous research works and the result of our own work indicate that osteoporosis is quite frequent in males. And 2014 - was declared year of " Man's Osteoporosis". One of three patients with the fracture of femoral bone is a male morality among males in higher that among females. High frequency of incidence of the risk factors among males is confirmed. Though, actually, there are no works about frequency of osteoporosis in the people, who consume the drugs illegally. Taking into consideration the high rate of spreading of the drugs all over the world and especially, in our, region we set the goal of studying of the bone metabolism among the drug consumers, regarding the term, narcotization, character of the drugs and their doses. There were examined 911 patients with narcotism, in the absitence period; among which 462 patients were heroin consumers and 449 buprenorphine consumers; age of the patients from 17 to 25. Average duration of the heroin narcotism- 4.5 years and of average period of buprenorphine narcotism- 1.5 years. Among the risk factors of osteoporosis. Among the studied patients there were revealed: hypogonadism (71-80%); low calcium diet (72%); mallabsorption syndrome (64%); low body mass (78%). All patients underwent measurements of bone tissue mineral density, by dual X-ray vertebras of limbar region, procimalsec-tion of he femoral bone, in the distal section of the forearm. In all cases there was studied the Ca-P balance, level of osteocalcine in the blood and activity of the alkali-phosphatase; level of general and free testosterone in the blood. The research result showed that the frequency of revealing of osteoporosis (T<-2.5), among the patients with heroin narcotism is 40-48% and frequency of revealing in the trabecular bines is higher, Frequency of low characteristics of the bone tissue, in case of buprenorphine narcotism is lower and varies between 30-35%. There was revealed reliable decrease of calcium and testosterone levels in the blood (p<0.05) and decrease of the free testosterone level in patients with heroin narcotism. There was revealed correlation between the duration of narcotisation and level of free testosterone in the patients with heroin narcotism (z =-0.58;p<0.001), on one hand and on the other correlation the mineral density of the bone tissue and the level of free testosterone (r=0.42;p<0.001). There is considered the issue of possible impact of the drugs on the bone metabolism process. It is recommended, for treatment of patients with narcotism, to include anti-osteoporosis preparation into complex therapy.

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DRUG USERS-RISK FACTOR OF OSTEOPOROSIS

About the authors

L LAGVILAVA

National Association of Osteoporosis

Georgia

M KOPALIANI

National Association of Osteoporosis

Georgia

L KTLASONTA

National Association of Osteoporosis

Georgia

N DOLIDZE

National Association of Osteoporosis

Georgia

N KTRVALTDZE

National Association of Osteoporosis

Georgia

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Copyright (c) 2016 LAGVILAVA L., KOPALIANI M., KTLASONTA L., DOLIDZE N., KTRVALTDZE N.

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