Vol 8, No 2 (2005)

Articles
IZMENENIYa KOSTNOY TKANI ChELOVEKAV KOSMIChESKOM POLETE: O VOZMOZhNYKh MEKhANIZMAKh OSTEOPENII
OGANOV V.S., BAKULIN A.V., NOVIKOV V.E., MURAShKO L.M., KABITsKAYa O.E.
Abstract
Some results of possible participation of bone metabolism regulation different levels in the bone changes caused by microgravity are presented taking into account the body fluid redistribution which usually accompany the space flight. The primary starting changes associate with biomechanical factors and realize on the strictly bone level (osteocytic osteolysis, breach of «collagen-crystal» connection, slowing of osteoblastic histogenesis). There are calcium homeostasis distortion on the extrabone (tissue, organs) level: decrease of calcium intestinal absorption and renal reabsorption. Changes in the hierarchy of ion and fluid volume regulation systems may provoke the osteoclastic resorption, which intensify the bone loss.
Osteoporosis and Bone Diseases. 2005;8(2):2-7
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ChASTOTA PERELOMOV BEDRA I PREDPLECh'Ya I ZATRATY NA IKh LEChENIE V MOSKOVSKOY OBLASTI
DREVAL' A.V., MARChENKOVA L.A., KRYuKOVA I.V.
Abstract
The aim of the study was to assess incidence of hip and distal forearm fractures and quality of the early medical aid and direct financial expenses for treatment those fractures in Moscow Region in the period of 1998-2002. Methods: For performing retrospective study among population aged 50 years Kolomensky area of Moscow Region was chosen. Source documents about patients with hip and distal forearm fractures were obtained from traumatologic hospital and traumatologic station of Kolomensky area. Cost of medical aid was calculated on the basis of the prices of the State Obligatory Medical Insurance of Russian Federation. Results: 527 hip fractures and 2420 distal forearm fractures were registered during 1998-2002. Hip fractures incidence varied from 77.1/100 000 to 156.6/100 000 among males (p<0.05) and from 166.1/100 000 to 216.0/100 000 among females (p>0.05). Distal forearm fractures incidence changed from 247.1/100 000 to 309.3/100 000 among males (p>0.05) and from 1213.0/100 000 to 1025.0/100 000 among females (p>0.05). Incidence of both fractures was significantly higher (p<0.01) in women than in men at all years of the study. Hip fractures incidence significantly grew with age with maximal values in age group >70 years old and there was no any dependence of distal forearm fractures incidence on age. Only 4% of hip fractures were surgically operated at the first 2 months after fracture. Direct financial expenses for treatment of patients with hip fracture for first the 2 months after fracture had made was over 582 - in average and early medical care cost for all hip fractures was about 104 714 - in Kolomensky area in the period of 1998-2002. Medical aid to patients with distal forearm fracture cost over 10- in average and financial expenses for treatment of all distal forearm fractures had made about 25 180 - in Kolomensky area for 5 years. We consider provisional amount of hip fractures may be about 23 500 and amount of distal forearm fractures may be about 105 300 during 1998-2002 in Moscow Region. Early medical care cost for all hip fractures was about 3 644 047- and for all distal forearm fractures about 876 264- in total in the period of study. Conclusions: Retrospective study among Moscow Region population aged 50 years revealed high incidence of hip and distal forearm fractures both in males and females in the period of 1998-2002. The investigation revealed that patients with hip fractures did not receive an adequate qualified medical aid and very high financial assets were spent for early medical care to fractures in Moscow Region.
Osteoporosis and Bone Diseases. 2005;8(2):8-13
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OSTEOPENIChESKIY SINDROM PRI ENDOKRINNYKh ZABOLEVANIYaKh V ZAPADNOY SIBIRI
NEKRASOVA M.R., SUPLOTOVA L.A., DAVYDOVA L.I., PRONYaKOVA O.V., PLATITsYNA N.G.
Abstract
West Siberia is the region, where annual sunlight days amount is very small because of geographical location in high latitudes. So, all inhabitants have high risk of vitamin D deficiency, what is proved OP fractures frequency studies. To estimate bone mineral density (BMD) loss in endocrinological patients, we performed 528 persons with such diseases as diabetes mellitus type 1, hypothyroidism, toxic goiter and glucocorticoid-dependent bronchial asthma. BMD was measured by DEXA method in forearm distal parts. Atraumatic fractures were registered in 15,3 %.We demonstrated high frequency of osteopenic syndrome (62,6-80%) in endocrine patients, more expressive in postmenopausal women. The received data allowed to determinate OP risk factors for our territory.
Osteoporosis and Bone Diseases. 2005;8(2):14-18
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PIS'MO V REDAKTsIYu
- -.
Abstract
Osteoporosis and Bone Diseases. 2005;8(2):20-20
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VLIYaNIE ISSLEDOVANIYa MINERAL'NOY PLOTNOSTI KOSTI (MPK) V STANDARTNYKh LOKALIZATsIYaKh I DOPOLNITEL'NYKh IZMERENIY MPK NA USTANOVLENIE DIAGNOZA OSTEOPOROZA
RUBIN M.P., ChEChURIN R.E.
Abstract
The aim of the study was to improve the quality of densitometric evaluations of bone mineral density disorders. Dual-energy x-ray absorbtiometry data collected in 874 females were analyzed. All patients had got bone mineral density examination of the lumbar spine, proximal femur at the both sides; some of the patients also had been measured at the distal radius. We hypothesize that the judgment of diagnostic categories (osteoporosis stages) should include consideration of bone mineral density data both for L2-L4 and for any of two adjacent vertebra, as well as variations of the femur neck data between the two sides. Ultradistal forearm bone densitometry was carried out for osteopenic patients who had had a Colles'fracture -to estimate fracture risk for the opposite radius. The osteoporotic fracture threshold for such cases may be at T-Score of -.1.
Osteoporosis and Bone Diseases. 2005;8(2):21-24
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OSOBENNOSTI POKAZATELEY UL'TRASONOMETRII ZhENSKOGO NASELENIYa GORODA ChELYaBINSKA
USOL'TsEVA E.N., SAFRONOV O.V., BRYuKhINA E.V.
Abstract
Characteristic feature of ultrasonic densitometry have been investigated in women,s population of Chelyabinsk (n=200) from 25 to 65 years old. We used domestically produced Echoosteometr-02. A basis of a body of the lower jaw became a new area for ultrasonic densitometry. We can recommend a lower jaw as a new area for ultrasonic densitometry taking into account high pithiness of data in a combination with simplicity of research. Traditional localizations have been also applied: proximal phalanges of the hand, patella, tibia diaphysis and calcaneus bones of the right and left sides. We have established a "peak" values of a speed of the ultrasound wave for the given bones. Also we have found that a tubular bones and a large spongy bone - a lower jaw - possess the highest speed of an ultrasound wave, and the speed was mach less in a small spongy bones, that is caused by their anatomic structure. Ultrasound densitometry parameters of the peripheral skeleton start to reduce from 40-50 years behind exception patella - from 55 years. The lowest values were in group of women of 60-65 years. The rates of ultrasonic densitometry received by us are possible to use for women population of Chelyabinsk.
Osteoporosis and Bone Diseases. 2005;8(2):25-28
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KOSTNYY METABOLIZM I POTERYa KOSTNOY TKANI V OTDALENNYE SROKI POSLE ALLOTRANSPLANTATsII TRUPNOY POChKI (ATP) (ODNOMOMENTNOE ISSLEDOVANIE)
ERMAKOVA I.P., PRONChENKO I.A., BUZULINA V.P., TOMILINA N.A., VEDERNIKOVA R.N., ERMOLENKO A.E., IL'NITsKIY V.V., ShUMAKOV V.I.
Abstract
Bone turnover markers [osteocalcin (OC), carboxyterminal procollagen I propeptide (PICP), bone alkaline phosphatase (bALP), deoxypyridinoline (DPD), β -crosslaps (CTX), bone acid phosphatase (bACP), parathyroid hormone (PTH)], day calcium excretion (uCaV) and lumbar and hip bone mineral content (BMC) were determined in 195 patients [78 women and 74 men with intact renal function as well as 11 women and 31 men with renal failure (RF)] 40±33 months following KT. KT recipients received triple immunosuppressive therapy (CysA, prednisolone and azathioprine). All groups showed bone remodeling dissociation namely bone resorption increase (high CTX, DPD, bACP) and bone formation retard (mild enhanced level OC, normal or low bALP) in association with high PTH, decreased uCaV and BMC levels. High bone turnover and low uCaV were much more high degree in RF. Vertebral and femur BMC decrease was mild (osteopenia) and only men with RF revealed peripheral osteoporosis. Hyperparathyroidism was associated with decreased transplant function and was main predictor of high bone turnover and bone loss after KT.
Osteoporosis and Bone Diseases. 2005;8(2):30-33
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MINERAL'NAYa PLOTNOST' KOSTEY SKELETA, MASSA MYShEChNOY, SOEDINITEL'NOY I ZhIROVOY TKANEY PRI MNOZhESTVENNYKh PERELOMAKh KOCTEY NIZhNIKh KONEChNOSTEY
SVEShNIKOV A.A., KARASEV A.G., SMOTROVA L.A.
Abstract
The mineral density of the fracture area, whole damaged limb and whole skeleton have been studied by mean Radiographic bi-energetical bone densitometer by «General Electric Medical Systems/Lunar» DPX line, model NT by the enCoreTM2002 program. At the same time we have evaluated a change of the weight of the muscular, connective and fat tissues both of the limb and the whole body. We were the fist who have been estimated the limb and the whole body area change. Bone mineral loss during fixation after double femoral fracture was 15%. One month after frame remove this figure was 7%, and after 1.5 years -4%. In the case of combined femoral and tibial fractures these indices were 22, 10 and 5%. These alterations of a mineral density should be take into account and corrected in order to activation of reparative process.
Osteoporosis and Bone Diseases. 2005;8(2):34-36
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VLIYaNIE STATINOV V SRAVNENII S KAL'TsIEM I VITAMINOM D NA POKAZATELI KOSTNOGO METABOLIZMA I MINERAL'NUYu PLOTNOST' KOSTNOY TKANI (MPK) U ZhENShchIN S OSTEOPENIEY V POSTMENOPAUZE
KRYZhOVA N.S., ROZhINSKAYa L.Y., ERMAKOVA I.P., IL'IN A.V., SAZONOVA N.I., MEL'NIChENKO G.A.
Abstract
An open clinical trial evaluating effects of Pravastatin (P) 20 mg, Fluvastatin (F) 40 mg versus Calcium-D3 Nycomed Forte (1000 mg calcium and 800 ME cholecalciferol - CaD3 ) on bone metabolism, bone mineral density (BMD) and lipid metabolism have been conducted. We studied 80 osteopenic women from 60 to 80 years old, divided into three groups: 30 participants were treated by CaD3 during 12 months, at the same time 30 ones applied P, and 20 women were treated by L for the 6 months. All of the remedies showed similar influence on the spine BMD (the basal BMD remained intact). CaD3 and L were able to prevent proximal hip from BMD loss whereas patients treated P proceeded to lose bone mass (up to 1.3-1.5%). We have found that CaD3 provides an antiresorptive action (СТх became 27.2% lower and OC -4.1%), that P doesn't touch bone metabolism indices and dual action of L: it suppress a bone resorption (СТх was 14,1% reduce) and show an invigorative action on bone formation (ОК 25,5% raised). The CaD3 treatment was the less expensive, and the highest cost had P course. Our comparative study reveals that CaD3 is preferable in solitary osteoporosis prevention. However when osteopenia or validity OP risk factors coexist with dyslipidemia, type II particularly, use of L may be rational because of it's 6th month therapy had rather equal effect to one of year CaD3 consumption.
Osteoporosis and Bone Diseases. 2005;8(2):37-43
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SOSTOYaNIE MINERAL'NOY PLOTNOSTI KOSTNOY TKANI I KOSTNOGO METABOLIZMA PRI SINDROME ShEREShEVSKOGO - TERNERA Obzor literatury
DRAGUN S.A., SEMIChEVA T.V., ANDREEVA E.N.
Abstract
Osteoporosis and Bone Diseases. 2005;8(2):44-48
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