Assotsiatsiya polimorfnogo varianta (CA)ngena kal'tsitonina (CALCA) s riskom razvitiyapostmenopauzal'nogo osteoporoza i urovnemkal'tsitonina v syvorotke krovi u russkikh zhenshchinVolgo-Ural'skogo regiona Rossii


Postmenopausal osteoporosis is a widespread complex disease with strong genetic predisposition. The aim of this study was to fnd association of (CA)n polymorphism of calcitonin gene (CALCA) with the risk of postmenopausal osteoporosis and serum calcitonin level in Russian women from Volga-Ural region. DNA samples of 372 women aged from 48 to 77 years old (175 with fractures and 197 without fractures) were used in the study. Femoral neck BMD was measured in 185 women, lumbal spine BMD - in 203 women. The serum calcitonin was measured in 168 women. Eight alleles of (CA)n polymorphism were revealed: each allele contained 10, 11, 12, 15, 16, 17, 18 and 19 CA repeats. CALCA*10*10 genotype is a marker of the decreased risk of osteoporosis (OR = 0,21) and osteopenia (OR = 0,21). CALCA*10*10 and CALCA*17*17 genotypes were shown to be
associated with high femoral neck BMD. Statistically signifcant association of CALCA*17 allele with the increased calcitonin level have been shown.

About the authors

L. I. Selezneva

R. I. Khusainova

R. Z. Nurlygayanov

E. A. Fazlyeva

T. M. Ziganshin

E. V. Kozhemyakina

O. M. Lesnyak

E. K. Khusnutdinova


  1. Alevizaki M., Stevenson J.C., Girgis S.I. et al. Altered calcitonin gene in a young patient with osteoporosis // BMJ. 1989. Vol. 6, № 298 (6682). P. 1215-1216.
  2. Andrew T., Antioniades L., Scurrah K.J. et al. Risk of wrist fracture in women is heritable and is infuenced by genes that are largely independent of those infuencing BMD // J Bone Miner Res. 2005. Vol. 20, № 1. P. 67-74.
  3. Beringer T.R., Ardill J., H. M. Taggart. Absence of evidence for a role of calcitonin in the etiology of femoral neck fracture // Calcif Tissue Int. 1986. Vol. 39, № 5. P. 300-303.
  4. Braga V., Mottes M., Mirandola S. et al. Association of CTR and COLIA1 alleles with BMD values in peri- and postmenopausal women // Calcif Tissue Int. 2000. Vol. 67, № 5. P. 361-366.
  5. Chesnut 3rd C.H., Baylink D.J, Sisom K. et al. Basal plasma immunoreactive calcitonin in postmenopausal osteoporosis // Metabolism . 1980. Vol. 29, № 6. P. 559-562.
  6. Drews K., Seremak-Mrozikiewicz A., Bartkowiak-Wieczorek J. et al. Genetic polymorphism of the calcitonin receptor gene and bone mineral density in Polish population of postmenopausal women // Ginekol Pol. 2005. Vol. 76, № 8. P. 612-618.
  7. Evans R., Marel G., Lancaster E. et al. Bone mass is low in relatives of osteoporosis patients // Ann Intern Med. 1988. Vol. 109. P 870-873.
  8. Kim J.G., Choi Y.M., Moon S.Y., Lee J.Y. Association of the calcitonin gene (CA) polymorphism with bone mass and bone responsiveness to hormone therapy in postmenopausal Korean women // Menopause. 2003. Vol. 10, № 6. P. 544-549.
  9. Magana J.J., Gomez R., Cisneros B. et al. Association of the CT gene (CA) polymorphism with BMD in osteoporotic Mexican women // Clin Genet. 2006. Vol. 70, № 5. P. 402-408.
  10. Mathew C.C. The isolation of high molecular weight eucariotic DNA // Methods in molecular biology. Ed Walker J.M. N.Y.; Haman press, 1984. P. 31-34.
  11. Miyao M., Hosoi T., Emi M. et al. Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus // J Hum Genet. 2000. Vol. 45, № 6. P. 346-350.
  12. Pondel M. Calcitonin and calcitonin receptors: bone and beyond // Int J Exp Pathol. 2000. Vol. 81, № 6. P. 405-422.
  13. Ralston S. The genetics of osteoporosis // Bone. 1999. Vol. 25, № 1. P. 85-86.
  14. Reginster J.Y. Calcitonin // Rev. Med. Liege. 1996. Vol. 51, № 1. P. 116-119.
  15. Seeman E., Hopper J., Bach L. et al. Reduced bone mass in daughters of women with osteoporosis // N. Engl. J. Med. 1989. Vol. 320. P. 554-558.
  16. Sugino K., Kure Y., Iwasaki H., Matsumoto A. Does total thyroidectomy induce metabolic bone disturbance? // Int. Surg. 1992. Vol. 77, № 3. P. 178-180.
  17. Tiegs R.D., Body J.J., Wahner H.W. et al. Calcitonin secretion in postmenopausal osteoporosis // N. Engl. J. Med. 1985. Vol. 25, № 312(17). P. 1097-1100.
  18. Tsukamoto K. A polymorphic CA repeat sequence at the human calcitonin locus // J. Hum. Genet. 1998. Vol. 43, № 2. P. 146-147.
  19. Uitterlinden A.G., van Meurs J.B., Rivadeneira F., Pols H.A. Identifying genetic risk factors for osteoporosis // J Musculoskelet Neuronal Interact. 2006. Vol. 6, № 1. P. 16-26.
  20. WHO technical report Assessment of fracture risk and its application to screening for postmenopausal osteoporosis // Geneva, 1994. ser. 843. p. 129.
  21. Wuster C., Raue F., Meyer C. et al. Long-term excess of endogenous calcitonin in patients with medullary thyroid carcinoma does not affect bone mineral density // J. Endocrinol. 1992. Vol. 134, № 1. P. 141-147.



Abstract - 700

PDF (Russian) - 126




Copyright (c) 2008 Selezneva L.I., Khusainova R.I., Nurlygayanov R.Z., Fazlyeva E.A., Ziganshin T.M., Kozhemyakina E.V., Lesnyak O.M., Khusnutdinova E.K.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies