EFFECTS OF INSULIN-LIKE GROWTH FACTOR TYPE I ON BONE REMODELING IN PHYSIOLOGICAL PREGNANCY AND NORMAL LEVELS OF VITAMIN D

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Abstract


During pregnancy the levels of IGF-I increase and in III trimester exceed greatly the values of I trimester. Its significant increase is noted from 22-24 weeks of pregnancy. Correlation analysis revealed a moderate negative correlation between the level of IGF-I in II trimester and distal forearm BMD (r = -0,35, p<0,5). Also a moderate positive correlation between the level of IGF-I and a marker of bone synthesis osteocalcin in the II and III trimesters of pregnancy was revealed (r = 0,46, p <0,05 and r = 0,41, p<0,05, respectively). Conclusions: IGF-I effects bone remodeling of long bones during pregnancy. It is probable that under the influence of IGF-I synthesis of bone matrix is increased, which in the presence of low calcium intake may be associated with reduced BMD at these bone sites.

About the authors

D S Sudakov

k.m.n., assistent kafedry akusherstva i ginekologii

T V Novikova

n. s. NIL reproduktsii i zdorov'ya zhenshchiny NII perinatologii i pediatrii

O S Bibkova

aspirant kafedry obshchey vrachebnoy praktiki

O V Galkina

k.b.n., zav. laboratoriey biokhimicheskogo gomeostaza organizma NII Nefrologii

I E Zazerskaya

Email: zazera@mail.гu
d.m.n., zamestitel' direktora po nauchnoy rabote NII perinatologii i pediatrii, zaveduyushchaya NIL reproduktsii i zdorov'ya zhenshchiny

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Copyright (c) 2012 Sudakov D.S., Novikova T.V., Bibkova O.S., Galkina O.V., Zazerskaya I.E.

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